CombiMatrix Influenza A Detection System can detect and accurately type influenza A strains in less than four hours. The CombiMatrix Influenza A Detection System accurately identifies hemagglutinin subtypes 1 through 16 and neuraminidase subtypes 1 through 9. In addition to providing very high-resolution information on the genotype of any previously identified strain, the Influenza A Detection System also provides information on novel strains of influenza A produced by rapid mutation or recombination in the genomes which define the serotype of these proteins. The microarray in the detection system, the Influenza A Research Microarray, has been tested and validated against both a representative RNA panel consisting of all influenza A serotypes as well as against amplified genomic material from a limited number of human and animal samples.

The Influenza A Research Microarray identifies strains by using standard polymerase chain reaction (PCR) with a universal influenza priming strategy and the use of multiple (tens to hundreds of) unique, sub-type specific probes on the array. The results are read electrochemically by the ElectraSense™ Reader.

USE OF THE COMBIMATRIX INFLUENZA A DETECTION SYSTEM

The Influenza A Detection System is cost effective, user-friendly and reliable. The Influenza A Detection System offers:

	The ability to detect all known strains of Influenza A, including differentiating between highly pathogenic and comparatively less pathogenic flu strains.
	A method that is highly sensitive to mutations in the influenza virus that maximize the likelihood of detecting new strains that have not been previously identified.
	A novel way to observe mutations and recombination events associated with changes in the genetic makeup of the virus.
	The ability to identify mixed populations of the flu.

RE-USE OF THE COMBIMATRIX INFLUENZA A MICROARRAY

CombiMatrix Influenza A Microarrays used in conjunction with the ElectraSense™ Reader can be stripped and re-used for a total of two times, further decreasing the cost of influenza detection. For more information on re-use, please see the information on the CustomArray™ Stripping Kit.

MICROARRY SERVICES FOR THE COMBIMATRIX INFLUENZA A MICROARRAY

CombiMatrix can also provide Influenza A Typing Services. Inactivated viral RNA samples can be processed at two facilities for rapid identification.

KITS AVAILABLE FOR THE INFLUENZA A TYPING SOLUTION

ElectraSense™ Influenza A Sub-typing Primers
The ElectraSense™ Influenza A Subtyping Primers Kit is used with the CombiMatrix ElectraSense™ platform and CombiMatrix Influenza A Research Microarray. The Influenza A Subtyping Primers Kit contains a common primer for reverse transcription, a common forward PCR primer, and four reverse PCR primer pools, two for HA, and another two for NA genes, and, a special positive hybridization control that is added to the hybridization buffer.

ElectraSense™ Detection Kit
The ElectraSense™ Influenza A Detection Kit detects and accurately types flu strains with hemagglutinin (HA) subtypes 1 through 15 and neuraminidase (NA) subtypes 1 through 9 during the post-hybridization labeling step of electro-chemical detection.

For more information fill out our contact form, telephone 800-985-2269 or email for more information.

ElectraSense™ Product Information

ElectraSense™ Specifications

ElectraSense™ Product Sheet (in .pdf format)

ElectraSense™ Reader and Software Manual

Influenza A Detection White Paper using ElectraSense™ (.pdf)

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